Neurobiology of Disease Pathological Changes in Dopaminergic Nerve Cells of the Substantia Nigra and Olfactory Bulb in Mice Transgenic for Truncated Human -Synuclein(1–120): Implications for Lewy Body Disorders
نویسندگان
چکیده
George K. Tofaris,1 Pablo Garcia Reitböck,1 Trevor Humby,2 Sarah L. Lambourne,2 Mark O’Connell,1 Bernardino Ghetti,3 Helen Gossage,1 Piers C. Emson,2 Lawrence S. Wilkinson,2 Michel Goedert,4 and Maria Grazia Spillantini1 1Centre for Brain Repair and Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 2PY, United Kingdom, 2The Babraham Institute, Cambridge CB2 4AT, United Kingdom, 3Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, and 4MRC Laboratory of Molecular Biology, Cambridge CB2 2QH, United Kingdom
منابع مشابه
More than a Rumor Spreads in Parkinson's Disease
As Parkinson's disease progresses, a massive loss of dopaminergic neurons is accompanied by accumulation of alpha-Synuclein (αSyn) neuronal inclusions called Lewy bodies and Lewy neurites. Inclusions first appear in olfactory bulb and enteric neurons then in ascendant neuroanatomical interconnected areas, and finally, in late stages of the disease, Lewy bodies are observed in a substantia nigra...
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Parkinson's disease (PD) is a neurodegenerative disorder classically characterized by the death of dopamine (DA) neurons in the substantia nigra pars compacta and by intracellular Lewy bodies composed largely of α-synuclein. Approximately 5-10% of PD patients have a familial form of Parkinsonism, including mutations in α-synuclein. To better understand the cell-type specific role of α-synuclein...
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